Breakthrough Discoveries for thriving with Bipolar Disorder, or BD², is a collective force transforming what we know about and how we treat bipolar disorder. It’s a commitment to the 40 million people living with bipolar disorder, those not yet diagnosed, and their loved ones.

Our vision is that breakthroughs in scientific understanding will create new interventions so that everyone living with bipolar disorder will thrive.

About BD²

Breakthrough Discoveries for thriving with Bipolar Disorder, or BD², is a collective force to transform what we know about and how we treat bipolar disorder. It’s a commitment to the 45 million people living with bipolar disorder, those not yet diagnosed, and their loved ones. The Baszucki, Brin, and Dauten families united with the Milken Institute to create BD² to advance discoveries for families like theirs. For too long, there have been limited advances in the study and treatment of bipolar disorder due to lack of collaboration and funding. BD² is establishing a network of interdisciplinary investigators to apply in-depth phenotyping, big data analytics, and an unprecedented data ecosystem to address bipolar disorder in an innovative, equitable, and rigorous way.

Opportunity Snapshot

Applicants are hereby invited to submit a finalized application for the purposes of site selection. All applicants who submit this form will be considered by the BD² program team for full application review for site participation in the Integrated Network. 

The Integrated Network is part of a multidisciplinary initiative to increase our understanding of the heterogeneity, progression, and underlying biology of bipolar disorder and, ultimately, to identify novel strategies for improved care and intervention.  In partnership with people living with bipolar disorder, clinicians, and researchers, the BD² Integrated Network will bring together a community committed to dramatically improving systems of care and accelerating research. The Integrated Network will generate in-depth clinical and biological data from a total of 4,000 longitudinal study participants. It will develop and subsequently launch a learning health network (LHN) with the goal of rapid integration of clinical care data analytics from research to inform clinical care. Applications demonstrating interest and an ability to capture in-depth, longitudinal, clinical, and biological data in a bipolar disorder LHN, will be considered.

Purpose

The purpose of the Integrated Network is to improve the health and well-being of people living with bipolar disorder by engaging a network of collaborating investigators and clinicians to:

  1. Implement and inform data-driven improvements in care
  2. Build an unprecedented data ecosystem for bipolar disorder comprised of longitudinal, clinical, and biological data
  3. Generate novel insights for interventional approaches

We are seeking the participation of investigators committed to realizing the vision of the initiative to build adaptive, networked approaches to mental health care and research. It is expected that investigators, and their associated health systems, will bring their leadership, capabilities, and resources to the effort.  They will demonstrate a long-term commitment to building and participating in a community ready to meet the challenges of providing better care for those living with bipolar disorder.

Funding

BD² intends to fund six sites during the first year of the program. This will expand to a network of up to 15 sites over three years. The anticipated award date for the initial six sites is approximately May 5, 2023.  Each applicant site may request $2,250,000 (USD) for use over five years to administer the longitudinal study cohort protocol and LHN as outlined in this RFA. This includes costs to recruit a goal of 100 BDI participants within the first year, collecting longitudinal data for an additional four years, and the necessary clinical and administrative process changes to support a learning health network within their institution. All grant totals are inclusive of indirect costs up to a maximum of 15% of the site budget.

Important Dates

  • December 15, 2022: Site Application Opens
  • February 1, 2022: Proposals Submission Deadline
  • February 1 - March 14, 2023: Reviews & Presentations (if deemed necessary)
  • May 5, 2023: Projected Award Notification Date
  • June 2023: Project Start
Breakthrough Discoveries for thriving with Bipolar Disorder